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Istradefylline 40 mg/working day enhanced peak concentrations and AUC of CYP3A4 substrates in scientific trials. This effect was not noticed with istradefylline 20 mg/day. Contemplate dose reduction of delicate CYP3A4 substrates.Observe Intently (1)crofelemer will increase levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.